Morachalcone A

Names

[ Name ]:
Morachalcone A

[Synonym ]:
2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dihydroxyphenyl)-, (2E)-
morachalchone A
BENZALACETOPHENONE
2,4,2',4'-tetrahydroxy-3'-prenylchalcone
MorachalconeA
Morachalcone A
1,3-diphenylprop-1-en-3-one
BENZYLIDENEACETOPHENONE
3-PHENYLACRYLOPHENONE
2-BENZALACETOPHENONE
1,3-di-phenyl-prop-2-en-1-one
(2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dihydroxyphenyl)-2-propen-1-one
trans-1,3-diphenyl-2-propen-1-one
PHENYL STYRYL KETONE
1,3-diphenyl-2-propen-1-one
TRANS-CHALCONE

Biological Activity

[Description]:

Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production[1][2][3].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

[References]

[1]. Brandt D R, et al. The synthetic preparation of naturally-occurring aromatase inhibitors, morachalcone A, isogemichalcone B, and isogemichalcone C[J]. Tetrahedron, 2013, 69(47): 9994-10002.

[2]. Kang Y J, et al. Inhibitory effects of morachalcone A on lipopolysaccharide-induced nitric oxide production in raw 264.7 cells[J]. 2009.

[3]. Ferlinahayati, et al. Phenolic constituents from the wood of Morus australis with cytotoxic activity. Z Naturforsch C J Biosci. 2008 Jan-Feb;63(1-2):35-9.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
605.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₀O₅

[ Molecular Weight ]:
340.37

[ Flash Point ]:
333.7±28.0 °C

[ Exact Mass ]:
340.131073

[ PSA ]:
97.99000

[ LogP ]:
5.24

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.680

Safety Information

[ Hazard Codes ]:
Xi

Morachalcone A

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds