Thiorphan

Names

[ Name ]:
Thiorphan

[Synonym ]:
N-[(RS)-2-Benzyl-3-mercaptopropanoyl]-glycine
DL-[N-(3-mercapto-2-benzylpropanoyl)]glycine
Glycine,N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-,(+-)
N-[(R,S)-3-mercapto-2-benzyl-propionyl]glycine
DL-Thiorphan
Tiorphan
(2-mercaptomethyl-3-phenyl-propionylamino)-acetic acid
Glycine, N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl)-, (±)-
Glycine, N-[3-mercapto-1-oxo-2-(phenylmethyl)propyl]-
N-(2-Benzyl-3-sulfanylpropanoyl)glycine
DL-3-Mercapto-2-benzylpropanoylglycine
Prestwick_694
N-(3-mercapto-2-benzylpropanoyl)glycine
(2-MERCAPTOMETHYL-3-PHENYL-PROPIONYL)-GLYCINE
(3-Mercapto-2-benzylpropionyl)glycine
Thiorphan

Biological Activity

[Description]:

Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Neprilysin

[References]

[1]. Whyteside AR, Turner AJ. Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Lett. 2008 Jul 9;582(16):2382-6.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
524.0±50.0 °C at 760 mmHg

[ Melting Point ]:
138-140ºC

[ Molecular Formula ]:
C₁₂H₁₅NO₃S

[ Molecular Weight ]:
253.32

[ Flash Point ]:
270.7±30.1 °C

[ Exact Mass ]:
253.077271

[ PSA ]:
105.20000

[ LogP ]:
1.37

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.577

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2930909090

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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