7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin

Names

[ Name ]:
7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin

[Synonym ]:
MFCD00077334
1-[4-[7-(diethylamino)-4-methyl-2-oxochromen-3-yl]phenyl]pyrrole-2,5-dione

Biological Activity

[Description]:

CPM is a maleimide derivative, acting as a blue fluorescent thiol-reactive dye. The excitation/emission maxima is 384/470 nm[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Grossman SH. Resonance energy transfer between the active sites of myocardial-type creatine kinase (isozyme MB). Biochemistry. 1983 Nov 8;22(23):5369-75.

Chemical & Physical Properties

[ Density]:
1.302 g/cm3

[ Boiling Point ]:
618.7ºC at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₂N₂O₄

[ Molecular Weight ]:
402.44200

[ Flash Point ]:
328ºC

[ Exact Mass ]:
402.15800

[ PSA ]:
70.83000

[ LogP ]:
4.10900

[ Index of Refraction ]:
1.648

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.

Biochem. Biophys. Res. Commun. 456(1) , 116-21, (2014)

G protein-coupled receptors (GPCRs) represent the largest family of transmembrane signaling proteins, and they are considered major targets of approximately half of all therapeutic agents. Human melan...

Identification of 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide (29) as an orally available MGAT2 inhibitor.

Bioorg. Med. Chem. 23 , 5922-31, (2015)

MGAT2 (monoacylglycerol acyltransferase 2) is expected to be an attractive target for the drug treatment of obesity, diabetes, and other disease. We describe our exploration and structure-activity rel...

N-terminal region of the catalytic domain of human N-myristoyltransferase 1 acts as an inhibitory module.

PLoS ONE 10 , e0127661, (2015)

N-myristoyltransferase (NMT) plays critical roles in the modulation of various signaling molecules, however, the regulation of this enzyme in diverse cellular states remains poorly understood. We prov...