N-Succinimidyl-S-acetylthioacetate

Names

[ Name ]:
N-Succinimidyl-S-acetylthioacetate

[Synonym ]:
N-Succinimidyl S-acetylthioglycolate
S-Acetylthioglycolic acid N-hydroxysuccinimide ester
S-acetylthioacetic acid N-hydroxysuccinimidyl ester
2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate
MFCD00036891
Ethanethioic acid, S-(2-((2,5-dioxo-1-pyrrolidinyl)oxy)-2-oxoethyl) ester
S-{2-[(2,5-Dioxopyrrolidin-1-yl)oxy]-2-oxoethyl} ethanethioate
N-succinimidyl S-Acetylthioacetate
Ethanethioic acid, S-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl] ester
S-{2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl} ethanethioate
2,5-dioxopyrrolidin-1-yl 2-(acetylsulfanyl)acetate
SATA
HSATA
N-hydroxysuccinimide S-acetylthioacetate

Biological Activity

[Description]:

N-Succinimidyl S-acetylthioacetate (SATA), a protein modification agent, introduces thiol-groups into protein molecules. N-Succinimidyl S-acetylthioacetate adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. J.L.M.Heeremans, et al. Interference of ϵ-amino-caproic acid with [N-succinimidyl S-acetylthioacetate derived] thiol-introduction into glu-plasminogen. Volume 8, Supplement 2, 1994, Pages 138-141.

[2]. Allen KJH, et al. Evaluation of N-Succinimidyl S-Acetylthioacetate Ligand for Radiolabeling of HumanizedAntibodies with 188Rhenium. Cancer Biother Radiopharm. 2018 Oct;33(8):349-355.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
337.3±44.0 °C at 760 mmHg

[ Melting Point ]:
84-89ºC

[ Molecular Formula ]:
C₈H₉NO₅S

[ Molecular Weight ]:
231.226

[ Flash Point ]:
157.8±28.4 °C

[ Exact Mass ]:
231.020142

[ PSA ]:
106.05000

[ LogP ]:
-1.16

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.562

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2930909090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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