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methsuximide

Names

[ CAS No. ]:
77-41-8

[ Name ]:
methsuximide

[Synonym ]:
Celontin
1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dion
1,3-dimethyl-3-phenyl-pyrrolidine-2,5-dione
mesuximid
Mesuximide
Mesuximida
Metsuccimide
Petinutin
methsuximide
Methsuximid
Mesuximidum

Biological Activity

[Description]:

Methsuximide is an anticonvulsant agent. Methsuximide is effective in petit mal, psychomotor and focal motor attacks[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. MARY LOUISE SCHOLL, et al. Celontin - a New Anticonvulsant.

Chemical & Physical Properties

[ Density]:
1.59g/cm3

[ Boiling Point ]:
489.2ºC at 760 mmHg

[ Melting Point ]:
52-53°

[ Molecular Formula ]:
C12H13NO2

[ Molecular Weight ]:
203.23700

[ Flash Point ]:
191.7ºC

[ Exact Mass ]:
203.09500

[ PSA ]:
37.38000

[ LogP ]:
1.27090

[ Index of Refraction ]:
1.692

[ Storage condition ]:
Refrigerator

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WN2625000
CHEMICAL NAME :
Succinimide, N,2-dimethyl-2-phenyl-
CAS REGISTRY NUMBER :
77-41-8
BEILSTEIN REFERENCE NO. :
0168315
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C12-H13-N-O2
MOLECULAR WEIGHT :
203.26
WISWESSER LINE NOTATION :
T5VNVTJ B1 D1 DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 6,740,1954 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
1006 mg/kg
SEX/DURATION :
female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 38,438,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6158 No. of Facilities: 29 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 876 (estimated) No. of Female Employees: 408 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H412

[ Precautionary Statements ]:
P301 + P312 + P330

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Precursor & DownStream


Related Compounds