Tigogenin

Names

[ CAS No. ]:
77-60-1

[ Name ]:
Tigogenin

[Synonym ]:
5α-Spirostan-3β-ol, (25R)-
TIGOGENIN
Tsosarsasaprgein
(3β,5α,25R)-Spirostan-3-ol
MFCD00067287
Ticogenin
(25R)-5a-Spirostan-3b-ol
(25R)-5α-Spirostan-3β-ol
Sisalagenin
Trigonegenin B
EINECS 201-041-9
Spirostan-3-ol, (3β,5α,25R)-

Biological Activity

[Description]:

Tigogenin, one of steroidal sapogenins, is widely used for synthesizing steroid drugs. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Zhou H, et al. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells. Mol Cell Endocrinol. 2007 May 30;270(1-2):17-22.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
516.6±20.0 °C at 760 mmHg

[ Melting Point ]:
202-204ºC

[ Molecular Formula ]:
C₂₇H₄₄O₃

[ Molecular Weight ]:
416.637

[ Flash Point ]:
266.2±21.8 °C

[ Exact Mass ]:
416.329041

[ PSA ]:
38.69000

[ LogP ]:
6.21

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.552

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH1443500

CHEMICAL NAME :: 5-alpha-Spirostan-3-beta-ol, (25R)-

CAS REGISTRY NUMBER :: 77-60-1

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C27-H44-O3

MOLECULAR WEIGHT :: 416.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29QKAZ "Toxins of Animal and Plant Origin, Proceedings International Symposium, 2nd, 1970," de Vries, A., and E. Kochva, eds., 3 vols., New York, Gordon and Breach Science Pub., 1971-73 Volume(issue)/page/year: 2,597,1972

Safety Information

[ Hazard Codes ]:
Xi

[ RTECS ]:
WH1443500

[ Hazard Class ]:
2.3

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%