BECLOMETASONE DIPROPIONATE MONOHYDRATE
Names
[ CAS No. ]:
77011-63-3
[ Name ]:
BECLOMETASONE DIPROPIONATE MONOHYDRATE
[Synonym ]:
4H7L9AI22I
beclomethasone dipropionate monohydrate
UNII-4H7L9AI22I
Biological Activity
[Description]:
Beclometasone dipropionate monohydrate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate monohydrate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma [1][2].
[Related Catalog]:
[In Vitro]
Beclometasone dipropionate monohydrate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells[2]. Western Blot Analysis[2] Cell Line: 16HBE cells Concentration: 1, 10 and 100 nM Incubation Time: 20 min Result: Reduced the levels of iNOS, ROS and NT generated by rhIL-17A.
[In Vivo]
Beclometasone dipropionate monohydrate (150 µg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number[1]. Animal Model: Male BALB/c mice with asthma[1] Dosage: 150 µg/kg Administration: Nebulization Result: Decreased total cell number and relative eosinophil number in BALF.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C34H51ClO12
[ Molecular Weight ]:
687.21500
[ Exact Mass ]:
686.30700
[ PSA ]:
190.80000
[ LogP ]:
4.98450