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(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11)

Names

[ CAS No. ]:
77128-69-9

[ Name ]:
(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11)

[Synonym ]:
5-Oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl-L-methioninamide
PGLU5,MEPHE8,SAR9-SUBSTANCE P FRAGMENT*5-11
PGLU-GLN-PHE-N-METHYL-PHE-SAR-LEU-MET-NH2
DiMe-C7
PYR-GLN-PHE-N-ME-PHE-SAR-LEU-MET-NH2
SUBSTANCE P (PGLU5,MEPHE8,SAR9)-*FRAGMEN T 5-11
L-Methioninamide, 5-oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl-
[GLP5,(ME)PHE8,SAR9] SUBSTANCE P (5-11)
GLP-GLN-PHE-(NME)PHE-SAR-LEU-MET-NH2
[pGlu5,MePhe8,Sar9]substance P(5-11)
(PYR5,N-ME-PHE8,SAR9)-SUBSTANCE P (5-11)
substance P (5-11),pGlu(5)-MePhe(8)-MeGly(9)

Biological Activity

[Description]:

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of cocaine-seeking behavior in rats[1][2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[In Vivo]

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (2 µg/side; inject into the ventral tegmental area; single) 选择性地激活大鼠大脑间脑和中脑皮层的多巴胺代谢[1]。 [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (0.5, 1.5, 3 µg/side; inject into the ventral tegmental area; single) 增加大鼠运动活性，诱导可卡因寻求行为的恢复[2]。 Animal Model: Male Sprague-Dawley rats (300-350 g)[1]. Dosage: 2 µg/side Administration: Inject into the ventral tegmental area; single Result: Selectively activated mesolimbic and mesocortical dopamine metabolism. Animal Model: Male Wistar rats (300-350 g)[2]. Dosage: 0.5, 1.5, 3 µg/side Administration: Inject into the ventral tegmental area; single Result: Significantly increased locomotor activity when at 3 µg/side.

[References]

[1]. Elliott PJ, et al. Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. Brain Res. 1986 Jan 15;363(1):145-7.  

[2]. Eison AS, et al. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions. Science. 1982 Jan 8;215(4529):188-90.  

[3]. Placenza FM, et al. Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats. Psychopharmacology (Berl). 2004 Dec;177(1-2):111-20.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1291.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C43H61N9O9S

[ Molecular Weight ]:
880.064

[ Flash Point ]:
734.7±34.3 °C

[ Exact Mass ]:
879.431274

[ PSA ]:
297.60000

[ LogP ]:
1.66

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.580

MSDS

Click to get detail MSDS

Related Compounds