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2-Aminoimidazole

Names

[ CAS No. ]:
7720-39-0

[ Name ]:
2-Aminoimidazole

[Synonym ]:
N-imidazolylamine
EINECS 231-751-4
1H-Imidazol-2-amine
MFCD00792530
2-aminoimidazole

Biological Activity

[Description]:

2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM[1][2][3].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Immunology/Inflammation >> Arginase
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

bacteria[1] Ki: 3.6 mM (human arginase I)[3]


[References]

[1]. Thompson RJ, et, al. Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent. Biochemistry. 2012 Dec 11;51(49):9776-8.

[2]. Jacobs L, et, al. 2-Aminoimidazoles as potent inhibitors of contaminating brewery biofilms. Biofouling. 2021 Feb 11;1-17.

[3]. Ilies M, et, al. 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. J Med Chem. 2010 May 27;53(10):4266-76.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
313.1±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C3H5N3

[ Molecular Weight ]:
83.092

[ Flash Point ]:
168.9±10.4 °C

[ Exact Mass ]:
83.048347

[ PSA ]:
54.70000

[ LogP ]:
-0.59

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.648

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-37/39

[ HS Code ]:
2933290090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


Related Compounds