MG 624

Names

[ CAS No. ]:
77257-42-2

[ Name ]:
MG 624

[Synonym ]:
Stilonium
Stilonium iodide
CCK Octapeptide,non-sulfated

Biological Activity

[Description]:

MG624 is a potent and selective neuronal α7 nAChR antagonist with a Ki of 106 nM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

[References]

[1]. Maggi L, et al. Selective effects of a 4-oxystilbene derivative on wild and mutant neuronal chick alpha7 nicotinic receptor. Br J Pharmacol. 1999 Jan;126(1):285-95.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₀NO+

[ Molecular Weight ]:
324.48000

[ Exact Mass ]:
324.23300

[ PSA ]:
9.23000

[ LogP ]:
5.11230

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S43

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
BS4305000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

4-Oxystilbene compounds are selective ligands for neuronal nicotinic alphaBungarotoxin receptors.

Br. J. Pharmacol. 124 , 1197, (1998)

1. Starting from the structure of an old 4-oxystilbene derivate with ganglioplegic activity (MG624), we synthesized two further derivates (F2 and F3) and two stereoisomers of F3 (F3A and F3B), and stu...