2-Guanidinoethylmercaptosuccinic Acid

Names

[ Name ]:
2-Guanidinoethylmercaptosuccinic Acid

[Synonym ]:
(2-guanidinoethylmercapto)succinic
DL-guanidinoethylmercaptosuccinic acid
2-(2-guanidinoethylthio) succinic acid
2-guanidinoethylmercaptosuccinic acid
gemsa
2-[(2-carbamimidamidoethyl)sulfanyl]succinic acid
Guanidinoethyl-Mercaptosuccinic Acid

Biological Activity

[Description]:

GEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

Encephalin convertase, Ki 值为8.8 nM.

[In Vitro]

GEMSA inhibits the activation of TAFI and porcine CBB[1]. GEMSA can inhibit the prolongation of lysis time in recombinant BAP and does not lead to the lysis of APC fibronectin[1]. GEMSA inhibits the prolongation of lysis time in porcine CPB, TAFI, and recombinant BAP, APC with the EC50 values of 0.34 μM, 100μM, 115 μM, 90 μM respectively[1][2].

[In Vivo]

GEMSA (ICV, 0.1μg/mg, every, 3days) results in a 75% increase in hypothalamic luteinizing hormone-releasing hormone and serum luteinizing hormone levels, and a 60% decrease in serum prolactin concentrations in rat[3]

[References]

[1]. B Przewlocka, et al. Analgesic and convulsant effects of guanidinoethylmercaptosuccinic acid (GEMSA)--a potent enkephalin convertase inhibitor. Neuropeptides. Nov-Dec 1986;8(4):359-65.

Chemical & Physical Properties

[ Density]:
1.59g/cm3

[ Boiling Point ]:
452.9ºC at 760 mmHg

[ Melting Point ]:
-180ºC (dec.)

[ Molecular Formula ]:
C₇H₁₃N₃O₄S

[ Molecular Weight ]:
235.26100

[ Flash Point ]:
227.7ºC

[ Exact Mass ]:
235.06300

[ PSA ]:
161.80000

[ LogP ]:
0.32150

[ Index of Refraction ]:
1.637

Safety Information

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
22-24/25

[ HS Code ]:
2930909090

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%