DL-m-Tyrosine

Names

[ CAS No. ]:
775-06-4

[ Name ]:
DL-m-Tyrosine

[Synonym ]:
DL-m-Tyrosine;; DL-3-Tyrosine;; 3-(3-Hydroxyphenyl)-DL-alanine
DL-M-TYROSINE
EINECS 212-270-9
3-hydroxy-phenylalanine
3-Hydroxy-DL-phenylalanine
DL-3-TYROSINE
D/L-3-hydroxy-phenylalanine
3-Hydroxyphenylalanine
DL-META-TYROSINE
D,L-M-TYR
M-TYROSINE
3-(m-Hydroxyphenyl)alanine
Phenylalanine, 3-hydroxy-
2-amino-3-(3-hydroxyphenyl)propanoic acid
UNII:45KGG1D4BI
2-ammonio-3-(3-hydroxyphenyl)propanoate
DL-3-OH-Phe
MFCD00002597

Biological Activity

[Description]:

DL-m-Tyrosine shows effects on Arabidopsis root growth. Carbidopa combination with DL-m-tyrosine shows a potent hypotensive effect[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Schuster B, et al. The mechanism of action of phenylalanine ammonia-lyase: the role of prosthetic dehydroalanine. Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8433-7.

[2]. Bertin C, et al. Grass roots chemistry: meta-tyrosine, an herbicidal nonprotein amino acid. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16964-9.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
387.2±32.0 °C at 760 mmHg

[ Melting Point ]:
280-285 °C (dec.)(lit.)

[ Molecular Formula ]:
C₉H₁₁NO₃

[ Molecular Weight ]:
181.189

[ Flash Point ]:
188.0±25.1 °C

[ Exact Mass ]:
181.073898

[ PSA ]:
83.55000

[ LogP ]:
0.38

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.614

[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YP2278000

CHEMICAL NAME :: m-Tyrosine, DL-

CAS REGISTRY NUMBER :: 775-06-4

BEILSTEIN REFERENCE NO. :: 2416853

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H11-N-O3

MOLECULAR WEIGHT :: 181.21

WISWESSER LINE NOTATION :: QVYZ1R CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02549 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1400 mg/kg

SEX/DURATION :: female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 38,251,1976

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YP2278000

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Pleiotropic physiological consequences of feedback-insensitive phenylalanine biosynthesis in Arabidopsis thaliana.

Plant J. 63(5) , 823-35, (2010)

A large proportion of plant carbon flow passes through the shikimate pathway to phenylalanine, which serves as a precursor for numerous secondary metabolites. To identify new regulatory mechanisms aff...

Concomitant tumor resistance: the role of tyrosine isomers in the mechanisms of metastases control.

Cancer Res. 72(5) , 1043-50, (2012)

Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. Although previous studies indicated that T-cell-d...

Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations.

J. Clin. Endocrinol. Metab. 86(6) , 2899-902, (2001)

ABSTRACT Since glucose intake acutely increases reactive oxygen species (ROS) generation by polymorphonuclear leucocytes (PMN) and mononuclear cells (MNC), we have now investigated whether a fast over...