Tetraethylene glycol monotosylate

Names

[ Name ]:
Tetraethylene glycol monotosylate

[Synonym ]:
toluene-4-sulfonic acid 2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl ester
tetraglycol-Ts
Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-,1-(4-Methylbenzenesulfonate)
[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl-4-methylbenzenesulfonate
Ts-tetraglycol
tetraethyleneglycol monotosylate

Biological Activity

[Description]:

Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Park KD, et al. Useful tools for biomolecule isolation, detection, and identification: acylhydrazone-based cleavable linkers.Chem Biol. 2009 Jul 31;16(7):763-72.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₄O₇S

[ Molecular Weight ]:
348.41200

[ Exact Mass ]:
348.12400

[ PSA ]:
110.67000

[ LogP ]:
1.21000

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H314

[ Precautionary Statements ]:
P280-P301 + P310-P305 + P351 + P338-P310

[ RIDADR ]:
UN 2927 8(6.1) / PGII

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%