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7-[(4-aminophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine

Names

[ CAS No. ]:
77681-42-6

[ Name ]:
7-[(4-aminophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine

Biological Activity

[Description]:

NSC309401 is an inhibitor of E. coli DHFR (IC50: 189 nM, KD: 14.57 nM)[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

189 nM (E. coli DHFR)[1]


[References]

[1]. Srinivasan B, et al. Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors. FEBS J. 2015 May;282(10):1922-38.  

Chemical & Physical Properties

[ Density]:
1.5g/cm3

[ Boiling Point ]:
710.3ºC at 760 mmHg

[ Molecular Formula ]:
C17H17ClN6

[ Molecular Weight ]:
340.81000

[ Flash Point ]:
383.4ºC

[ Exact Mass ]:
340.12000

[ PSA ]:
108.77000

[ LogP ]:
4.92500

[ Index of Refraction ]:
1.797