Velaresol

Names

[ Name ]:
Velaresol

[Synonym ]:
BW 12C
Velaresol
12C79
5-(2-Formyl-3-hydroxyphenoxy)valeric acid
EINECS 278-778-8
2-4'-carboxybutoxy-6-hydroxybenzaldehyde
12C
Pentanoic acid,5-(2-formyl-3-hydroxyphenoxy)

Biological Activity

[Description]:

Velaresol (BW 12C) is a potent left-shifting anti-sickling compound in vitro[1]. Sickle cell disease is an inherited disorder of the hemoglobin molecule. When hemoglobin molecules are exposed to a variety of environments, the red blood cell hemoglobin polymerizes, twists, and morphs into a sickle shape.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Fitzharris P, et al. The effects in volunteers of BW12C, a compound designed to left-shift the blood-oxygen saturation curve. Br J Clin Pharmacol. 1985 Apr;19(4):471-81.

Chemical & Physical Properties

[ Density]:
1.293g/cm3

[ Boiling Point ]:
452.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₄O₅

[ Molecular Weight ]:
238.24

[ Flash Point ]:
176.1ºC

[ Exact Mass ]:
238.08400

[ PSA ]:
83.83000

[ LogP ]:
1.83840

[ Index of Refraction ]:
1.584

[ Storage condition ]:
-20℃

Safety Information

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%