MY-5445

Names

[ Name ]:
MY-5445

[Synonym ]:
MY-5445
N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine
Tocris-0432
N-(3-chlorophenyl)-4-phenylphthalazin-1-amine
1-Phthalazinamine, N-(3-chlorophenyl)-4-phenyl-

Biological Activity

[Description]:

MY-5445 is a specific phosphodiesterase type 5 (PDE5) inhibitor[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[Target]

PDE5

[References]

[1]. Nagendran J, et al. Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation. 2007 Jul 17;116(3):238-48.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
539.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₄ClN₃

[ Molecular Weight ]:
331.80

[ Flash Point ]:
280.2±30.1 °C

[ Exact Mass ]:
331.087616

[ PSA ]:
37.81000

[ LogP ]:
5.42

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.712

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26;S36