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Bermoprofen

Names

[ CAS No. ]:
78499-27-1

[ Name ]:
Bermoprofen

[Synonym ]:
2-(8-methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)propionic acid
Bermoprofen
2-(8-Methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)-propionic acid
2-(8-methyl-10,11-dihydro-11-oxodibenz<b,f>oxepin-2-yl)propionic acid
bermoprofen
2-(8-methyl-10,11-dihydro-11-oxodibenz(b,f)oxepin-2-yl)propionic acid
2-(8-Methyl-11-oxo-10,11-dihydro-dibenzo[b,f]oxepin-2-yl)-propionic acid

Biological Activity

[Description]:

Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory agent. Bermoprofen has potent antipyretic and analgesic activities with a short biological half-life. Bermoprofen is a potent antagonist of LPS-induced fever in rabbits[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

Bermoprofen (AD-1590) shows ulcerogenic activity as a side-effect like other nonsteroidal anti-inflammatory agents[1].

[In Vivo]

Bermoprofen (AD-1590) (0.04-0.1 mg/kg; p.o.) shows a dose-related antipyretic activity in LPS-induced febrile rabbits[2]. Animal Model: Male albino rabbits, 2.3-3 kg[2] Dosage: 0.04, 0.4, 0.1 mg/kg Administration: Oral; given 1 h after i.v. injection of LPS Result: Inhibited significantly the rise in rectal temperature at doses of 0.1 mg/kg or more, the temperature returned approximately to normal after 0.4 mg/kg.

[References]

[1]. Mori M, et al. Prolongation of antipyretic action and reduction of gastric ulcerogenicity in the rat by controlled-release granules of bermoprofen, a new nonsteroidal anti-inflammatory drug. J Pharm Sci. 1991 Sep;80(9):876-80.

[2]. Nakamura H, et al. AD-1590, a potent antagonist of lipopolysaccharide-induced fever in rabbits. J Pharm Pharmacol. 1984 Mar;36(3):182-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H16O4

[ Molecular Weight ]:
296.31700

[ Exact Mass ]:
296.10500

[ PSA ]:
63.60000

[ LogP ]:
3.71420

Related Compounds