Cycloastragenol

Names

[ Name ]:
Cycloastragenol

[Synonym ]:
9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-, (3β,6α,9β,16β,20R,24S)-
Astramembrangenin
(3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-, (3β,6α,9β,16β,20R,24R)-
Cycloastragenol
(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegigenin

Biological Activity

[Description]:

Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge[1].Astramembrangenin is orally safe and has broad Extensive pharmacological effects, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties[2].Astramembrangenin has antiaging properties, CAG stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Cycloastragenol (CAG) may have a novel therapeutic role in depression[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[In Vitro]

Astramembrangenin (0-10 µM; 3-6 days) increases cell growth compared to the vehicle control in HEK cultures[1]. Astramembrangenin (0.3 µM; 5-90 mins) induces CREB phosphorylation in primary cortical neurons, total CREB expression is unaltered by CAG in both cell type[1]. Astramembrangenin (3 µM; 6-48 hours) may promotes prosurvival signaling in neurons, increases tert mRNA expression, exhibits increased bcl2 mRNA expression[1]. Cell Viability Assay[1] Cell Line: HEK cells Concentration: 1 µM, 3 µM, 10 µM Incubation Time: 3-6 days Result: Doubled the cell growth at 6 days. Western Blot Analysis[1] Cell Line: Neuronal cells Concentration: 0.3 µM Incubation Time: 5 mins, 15 mins, 30 mins, 90 mins Result: Suggested that CAG induces CREB activation in neuronal cells. RT-PCR[1] Cell Line: Neuronal cells Concentration: 3 µM Incubation Time: 6-48 hours Result: Increased tert, bcl2 mRNA expression.

[References]

[1]. Ip FC, et al. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014;22(1):52-63.

[2]. Yu Y, et al. Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 2018 Sep;16(3):2175-2182.

[3]. Sun C, et al. Cycloastragenol mediates activation and proliferation suppression in concanavalin A-induced mouse lymphocyte pan-activation model. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):131-139.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
617.2±55.0 °C at 760 mmHg

[ Melting Point ]:
241.0 to 245.0 °C

[ Molecular Formula ]:
C₃₀H₅₀O₅

[ Molecular Weight ]:
490.715

[ Flash Point ]:
327.1±31.5 °C

[ Exact Mass ]:
490.365814

[ PSA ]:
90.15000

[ LogP ]:
3.82

[ Vapour Pressure ]:
0.0±4.0 mmHg at 25°C

[ Index of Refraction ]:
1.582

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
GX8265000

[ HS Code ]:
2942000000

Customs

[ HS Code ]: 2942000000

Articles

Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management.

Neurosignals 22(1) , 52-63, (2014)

Cycloastragenol (CAG) is an aglycone of astragaloside IV. It was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. The present study de...

A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis.

PLoS ONE 8(3) , e58423, (2013)

The emergence of diseases associated with telomere dysfunction, including AIDS, aplastic anemia and pulmonary fibrosis, has bolstered interest in telomerase activators. We report identification of a n...

Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes.

J. Immunol. 181(10) , 7400-6, (2008)

Telomerase reverse transcribes telomere DNA onto the ends of linear chromosomes and retards cellular aging. In contrast to most normal somatic cells, which show little or no telomerase activity, immun...