FSBA

Names

[ Name ]:
FSBA

[Synonym ]:
5'-O-[4-(Fluorosulfonyl)benzoyl]adenosine hydrochloride (1:1)
Adenosine, 5'-[4-(fluorosulfonyl)benzoate], hydrochloride (1:1)
MFCD00043258

Biological Activity

[Description]:

FSBA? hydrochloride is a useful reagent for the affinity labeling of adenine nucleotide binding proteins and is mainly applied in the study of purified The labeling and subsequent detection of? these proteins can be blocked by including an excess of MgATP, which competes with FSBA for nucleotidebinding sites[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Anostario, M., Harrison, M. L., & Geahlen, R. L. (1990). Immunochemical detection of adenine nucleotide-binding proteins with antibodies to 5′-p-fluorosulfonylbenzoyladenosine. Analytical Biochemistry, 190(1), 60–65.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₇ClFN₅O₇S

[ Molecular Weight ]:
489.863

[ Exact Mass ]:
489.052124

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Radioresistant Sf9 insect cells undergo an atypical form of Bax-dependent apoptosis at very high doses of γ-radiation.

Int. J. Radiat. Biol. 89(12) , 1017-27, (2013)

To investigate the underlying mechanisms of cell-death at extremely high doses of radiation in radioresistant Spodoptera frugiperda-9 (Sf9) insect cells.Morphology, cell proliferation and DNA-fragment...

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction.

Mol. Cell. Biol. 16 , 1722-1733, (1996)

Wortmannin at nanomolar concentrations is a potent and specific inhibitor of phosphoinositide (PI) 3-kinase and has been used extensively to demonstrate the role of this enzyme in diverse signal trans...

Vesicular transport and apotransferrin in intestinal iron absorption, as shown in the Caco-2 cell model.

Am. J. Physiol. Gastrointest. Liver Physiol. 290 , G301-G309, (2006)

The potential roles of vesicular transport and apotransferrin (entering from the blood) in intestinal Fe absorption were investigated using Caco-2 cell monolayers with tight junctions in bicameral cha...