4-[4-(2-Aminoethyl)-2-iodophenoxy]phenol Hydrochloride

Names

[ Name ]:
4-[4-(2-Aminoethyl)-2-iodophenoxy]phenol Hydrochloride

[Synonym ]:
Phenol,4-[4-(2-aminoethyl)-2-iodophenoxy]-,hydrochloride
2-[4-(4-Hydroxyphenoxy)-3-iodophenyl]ethanaminium chloride
4-[4-(2-Aminoethyl)-2-iodophenoxy]phenol Hydrochloride
3-Iodothyronamine Hydrochloride
Phenol, 4-[4-(2-aminoethyl)-2-iodophenoxy]-, hydrochloride (1:1)

Biological Activity

[Description]:

3-Iodothyronamine (hydrochloride) is an endogenous and rapid-acting derivative of thyroid hormone. 3-Iodothyronamine potently activates an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale. 3-Iodothyronamine can be used for the research of congestive heart failure[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Hart ME, et al. Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J Med Chem. 2006 Feb 9;49(3):1101-12.

Chemical & Physical Properties

[ Melting Point ]:
209-211ºC

[ Molecular Formula ]:
C₁₄H₁₅ClINO₂

[ Molecular Weight ]:
391.63

[ Exact Mass ]:
390.983582

[ PSA ]:
55.48000

[ LogP ]:
4.79260

Safety Information

[ Hazard Codes ]:
C