PEG2-Cl

Names

[ CAS No. ]:
78925-46-9

[ Name ]:
PEG2-Cl

[Synonym ]:
1-Propanol, 3-(2-chloroethoxy)-
3-(2-Chloroethoxy)-1-propanol
3-(2-chloroethoxy)propan-1-ol

Biological Activity

[Description]:

PEG2-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
236.9±15.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅H₁₁ClO₂

[ Molecular Weight ]:
138.593

[ Flash Point ]:
97.1±20.4 °C

[ Exact Mass ]:
138.044754

[ PSA ]:
29.46000

[ LogP ]:
0.26

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.441

PEG2-Cl

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Related Compounds