Yakuchinone A
Names
[ CAS No. ]:
78954-23-1
[ Name ]:
Yakuchinone A
[Synonym ]:
yakuchinone-A
1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-3-heptanone
yadanzioside-N
Biological Activity
[Description]:
Yakuchinone A is a natural product isolated from the fruit of Alpinia oxyphylla, which can induce apoptosis and has anticancer and anti-inflammatory activities[1].
[Related Catalog]:
[In Vitro]
Yakuchinone A 作用于 A375P、B16F1、B16F10、A549、MCF-7 和 HT-29 细胞系的 IC50 值分别是 14.75、31.73、21.71、26.07 、11.50 和 11.96[1]。 Yakuchinone A (0-64 μM, 16 h) 可以剂量依赖性方式减少 IL-17 的产生,在 EL4(小鼠淋巴瘤细胞系)细胞中的 IC50 值为 11.5 μM[2] 。
[In Vivo]
Yakuchinone A (50 mg/kg, i.p., daily, 14 days) 在自身免疫性脑脊髓炎 (EAE) 小鼠模型中可以减轻小鼠的 EAE 症状[1]。 Animal Model: Female C57BL/6 mice[1] Dosage: 50 mg/kg Administration: i.p., daily, 14 days Result: Showed a significant EAE score reduction from Day 9 to Day 15 after EAE onset.
[References]
Chemical & Physical Properties
[ Density]:
1.095g/cm3
[ Boiling Point ]:
495.8ºC at 760 mmHg
[ Molecular Formula ]:
C20H24O3
[ Molecular Weight ]:
312.40
[ Flash Point ]:
174.3ºC
[ Exact Mass ]:
312.17300
[ PSA ]:
46.53000
[ LogP ]:
4.31550
[ Index of Refraction ]:
1.559
[ Storage condition ]:
2-8°C