D-AP5(mM/ml)

Names

[ Name ]:
D-AP5(mM/ml)

[Synonym ]:
D(-)-APV
UNII:39PJ29YY8Z
[3H]-D(-)-2-Amino-5-phosphonopentanoic acid
5-Phosphononorvaline
D-2-Amino-5-phosphonovaleric acid
D-2-Amino-5-phosphopentanoic acid
D-Norvaline,5-phosphono
5-Phosphono-D-norvaline
Norvaline, 5-phosphono-
5-PHOSPHONO-DL-NORVALINE
D-AP5
D(-)-2-Amino-5-phosphonopentanoic acid

Biological Activity

[Description]:

D-AP5 is a NMDA receptor antagonist.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

[Target]

NMDA[1]

[In Vivo]

D-AP5 is a NMDA receptor antagonist. Chronic intraventricular infusion of D-AP5 causes a parallel dose-dependent impairment of spatial learning and long-term potentiation (LTP) in vivo. Intracerebral concentrations of D-AP5 fail to induce any measurable sensorimotor disturbance when spatial learning is prevented[1]. D-AP5 infusion is associated with a progressive reduction in swim speed over trials. D-AP5 causes sensorimotor disturbances in the spatial task, but these gradually worsened as the animals fail to learn. Rats treated with D-AP5 show a delay-dependent deficit in spatial memory in the delayed matching-to-place protocol for the water maze[2].

[Animal admin]

Male Lister hooded rats are used in this study. They are housed individually and have free access to food and water at all times except for 12 hr prior to surgery. Animals are implanted with 30 mM D-AP5 (N=6) and tested in the water maze[1].

[References]

[1]. Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34.

[2]. Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
482.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅H₁₂NO₅P

[ Molecular Weight ]:
197.126

[ Flash Point ]:
245.4±31.5 °C

[ Exact Mass ]:
197.045303

[ PSA ]:
130.66000

[ LogP ]:
-2.32

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.536

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

Articles

Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation.

Antioxid. Redox Signal. 22(9) , 772-84, (2015)

Several neurodegenerative disorders show alterations in glutamatergic synapses and increased susceptibility to excitotoxicity. Mounting evidence suggests a central role for the cellular prion protein ...

Properties of a Glutamatergic Synapse Controlling Information Output from Retinal Bipolar Cells.

PLoS ONE 10 , e0129133, (2015)

One general categorization of retinal ganglion cells is to segregate them into tonically or phasically responding neurons, each conveying discrete aspects of the visual scene. Although best identified...

A1 adenosine receptor-mediated GIRK channels contribute to the resting conductance of CA1 neurons in the dorsal hippocampus.

J. Neurophysiol. 113 , 2511-23, (2015)

The dorsal and ventral hippocampi are functionally and anatomically distinct. Recently, we reported that dorsal Cornu Ammonis area 1 (CA1) neurons have a more hyperpolarized resting membrane potential...