S-(-)-Warfarin-d5

Names

[ CAS No. ]:
791013-22-4

[ Name ]:
S-(-)-Warfarin-d5

Biological Activity

[Description]:

S-(-)-Warfarin-d5 is deuterium labeled S-(-)-Warfarin. S-(-)-Warfarin is a more potent enantiomer of Warfarin as a vitamin K antagonist with anticoagulant effect[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Bai J, et al. Metabolic profiling of HepG2 cells incubated with S(-) and R(+) enantiomers of anti-coagulating drug warfarin. Metabolomics. 2011 Sep;7(3):353-362.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H11D5O4

[ Molecular Weight ]:
313.36

[ Exact Mass ]:
313.13600

[ PSA ]:
67.51000

[ LogP ]:
3.60960

Related Compounds