JNJ-1289

Names

[ Name ]:
JNJ-1289

Biological Activity

[Description]:

JNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

IC50: 50 nM (hSMOX)[1]; >2 μM (hPAOX and LSD1)[1].

[In Vitro]

JNJ-1289 (0 and 2 h) inhibits hSMOX activity in a time-dependent manner[1]. JNJ-1289 initially forms a weak complex with hSMOX with an apparent Ki value of 1.4 μM, followed by a relatively slow protein isomerization that forms the final tightly bound inhibitor-enzyme complex[1].

[References]

[1]. Elsie Diaz, et al. B Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor. Commun Biol. 2022 Aug 5;5(1):787.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₂N₄OS

[ Molecular Weight ]:
308.36

JNJ-1289

Names

Biological Activity

Chemical & Physical Properties

Related Compounds