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DCLX069

Names

[ CAS No. ]:
792946-69-1

[ Name ]:
DCLX069

[Synonym ]:
MFCD06666140
Benzoic acid, 3-amino-4-[4-(phenylmethyl)-1-piperazinyl]-, ethyl ester
Ethyl 3-amino-4-(4-benzyl-1-piperazinyl)benzoate

Biological Activity

[Description]:

DCLX069 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 value of 17.9 µM. DCLX069 shows less active against PRMT4 and PRMT6. DCLX069 has anticancer effects[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[Target]

PRMT1:17.9 μM (IC50)


[In Vitro]

DCLX069 (12.5-100 µM) effectively blocks cell proliferation in breast cancer, liver cancer and acute myeloid leukemia cell lines (MCF7, HepG2, and THP1 cells) in a concentration-dependent manner[1].

[References]

[1]. Yiqian Xie, et al. Virtual screening and biological evaluation of novel small molecular inhibitors against protein arginine methyltransferase 1 (PRMT1). Org Biomol Chem. 2014 Dec 21;12(47):9665-73.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
515.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H25N3O2

[ Molecular Weight ]:
339.431

[ Flash Point ]:
265.8±30.1 °C

[ Exact Mass ]:
339.194672

[ LogP ]:
2.63

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.611

Related Compounds