Methyl aminolevulinate hydrochloride

Names

[ Name ]:
Methyl aminolevulinate hydrochloride

[Synonym ]:
MFCD00012868
Pentanoic acid, 5-amino-4-oxo-, methyl ester, hydrochloride (1:1)
Metvixia
Methyl 5-amino-4-oxopentanoate hydrochloride (1:1)
Methyl aminolevulinate hydrochloride
methyl 5-amino-4-oxopentanoate,hydrochloride
Methyl 5-Aminolevulinate Hydrochloride
EINECS 279-151-1
5-Aminolevulinic acid methyl ester HCl
Metvix PDT
5-Aminolevulinic acid methyl ester hydrochloride

Biological Activity

[Description]:

Methyl aminolevulinate hydrochloride is an agent used as a sensitizer in photodynamic therapy (PDT). Methyl aminolevulinate is a prodrug that can be metabolized to Protoporphyrin IX[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Methyl aminolevulinate, From Wikipedia

Chemical & Physical Properties

[ Boiling Point ]:
228ºC at 760 mmHg

[ Melting Point ]:
122 °C

[ Molecular Formula ]:
C₆H₁₂ClNO₃

[ Molecular Weight ]:
181.617

[ Flash Point ]:
99.5ºC

[ Exact Mass ]:
181.050568

[ PSA ]:
69.39000

[ LogP ]:
0.96970

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Multidimensional visualization of healthy and sensitized rabbit knee tissues by means of confocal microscopy.

J. Biomed. Opt. 20 , 051035, (2015)

This study combines several fluorescence detection methods to distinguish structural features of the synovium and cartilage tissues and to visualize the localization of endogenous porphyrins in the se...

Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part I. Acne vulgaris: when and why consider photodynamic therapy? Sakamoto FH, Lopes JD, Anderson RR.

J. Am. Acad. Dermatol. 63 , 193-194, (2010)

Photodynamic therapy: current evidence and applications in dermatology.

Semin. Cutan. Med. Surg. 30 , 199-209, (2011)

Photodynamic therapy (PDT) involves the activation of a photosensitizing drug, which preferentially localizes to diseased skin, by irradiation with light to cause selective cytotoxic damage. Since its...