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Azido-PEG1-CH2COO-Cl

Names

[ CAS No. ]:
79598-49-5

[ Name ]:
Azido-PEG1-CH2COO-Cl

Biological Activity

[Description]:

Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker. Azido-PEG1-CH2COO-Cl can be used in the synthesis of PROTAC BRD4 Degrader-1 (HY-133131)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether


[In Vitro]

PROTAC BRD4 Degrader-1 is an efficacious BRD4 degrader with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression[1].

[References]

[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.Bioorg Med Chem. 2020 Jan 1;28(1):115228.

Chemical & Physical Properties

[ Molecular Formula ]:
C4H6ClN3O2

[ Molecular Weight ]:
163.56

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds