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Lovastatin Diol Lactone

Names

[ CAS No. ]:
79952-42-4

[ Name ]:
Lovastatin Diol Lactone

[Synonym ]:
Antibiotic MB 530A
(4R,6R)-4-Hydroxy-6-{2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]ethyl}tetrahydro-2H-pyran-2-one
2H-Pyran-2-one, 6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-, (4R,6R)-
Monacolin J
(4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-4-hydroxyoxan-2-one
Lovastatin diol lactone
Simvastatin EP Impurity H

Biological Activity

[Description]:

Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)
Research Areas >> Metabolic Disease

[Target]

HMG-CoA reductase[1]


[In Vitro]

Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase. Na salt of Monacolin J causes 50% inhibition on reductase at 1.2 μg/mL[1].

[References]

[1]. Endo A, et al. Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber. J Antibiot (Tokyo). 1985 Mar;38(3):420-2.


[Related Small Molecules]

Rosuvastatin Calcium | Fluvastatin Sodium | Pravastatin (sodium) | Mevastatin | Nicodicosapent | Clinofibrate | SR-12813 | 3-hydroxy-3-methylglutaric acid

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
535.7±50.0 °C at 760 mmHg

[ Melting Point ]:
104-114 °C

[ Molecular Formula ]:
C19H28O4

[ Molecular Weight ]:
320.423

[ Flash Point ]:
191.2±23.6 °C

[ Exact Mass ]:
320.198761

[ PSA ]:
66.76000

[ LogP ]:
1.81

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.558

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds