Corn oil

[Description]:

Corn oil, extracted from the germ of corn, can be used as a carrier for drug molecules and has anti-tumor activity.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Biochemical Assay Reagents

Research Areas >> Cancer

[In Vivo]

Corn oil-gavaged rats have ~25% lower MNCL incidence as well as longer MNCL latency and increase survival. Corn oil-gavaged rats have 54% lower serum growth hormone (GH) levels, and replacement of GH into corn oil-gavaged rats by osmotic minipump infusion increase in situ MNCL cell proliferation to rates observed in water-gavaged animals. Corn oil-gavaged rats, which receive 5 mL corn oil /kg body wt/day for 5 days/week, have a 3-fold increase in fat intake compared to nongavaged or water-gavaged control rats[1]. Intraperitoneal injection of trace amounts of corn oil prior to and following the injection of 40u201350 mg of tissue from hepatoma 7777 or 7800 into the thigh of adult male Buffalo rats result in a marked decrease in the growth rate of both tumors[2].

[Animal admin]

Rats[1] Male and female F344 rats (50 days of age are individually housed in polycarbonate cages on hardwood bedding in rooms maintained at 24°C with 12 h light/dark cycles. All rats are given unlimited access to distilled water and NIH-07 open formula diet. Orally gavaged animals receive corn oil or distilled water 5 days/week at a volume of 5 mL/kg body wt/day[1].

[References]

[1]. Hursting SD, et al. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis. 1994 Feb;15(2):193-9.

[2]. Gilbertson JR, et al. Inhibition of growth of Morris hepatomas 7777 and 7800 by corn oil. Oncology. 1977;34(2):62-4.

[Related Small Molecules]

[ Density]:
0.900 g/mL at 20 °C

[ Flash Point ]:
254 °C

[ Index of Refraction ]:
1.473-1.476

[ Storage condition ]:
0-6°C

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
F+

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
-

[ RTECS ]:
GM4800000

[ HS Code ]:
15152910

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