2-(3-HYDROXY-2-(3-HYDROXYPICOLINAMIDO)PHENYL)BENZO[D]OXAZOLE-4-CARBOXYLIC ACID
Names
[ CAS No. ]:
80148-45-4
[ Name ]:
2-(3-HYDROXY-2-(3-HYDROXYPICOLINAMIDO)PHENYL)BENZO[D]OXAZOLE-4-CARBOXYLIC ACID
Biological Activity
[Description]:
Antibiotic A-338533, an antibiotic, can be isolated from Streptomyces strain. Antibiotic A-338533 has anti-bacterial activity against Staphylococcus aureus, Mycoplasma gallisepticum with MIC values of 2 μg/mL and ≤1.56 μg/mL, respectively[1].
[Related Catalog]:
[In Vitro]
Antibiotic A-33853 对球虫病的主要致病菌嫩艾美耳菌 (Eimeria tenella) 有抑制作用,对阴道毛滴虫 (Trichomonas vaginalis) 的 MIC<0.975 μg/mL[1]。
[In Vivo]
Antibiotic A-33853 (60 mg/kg;皮下注射;单次剂量) 对雏鸡体内的鸡毒支原体无效[1]。 Antibiotic A-33853 (70 mg/kg;皮下注射;两次剂量) 对小鼠体内的金黄色葡萄球菌无效[1]。 Antibiotic A-33853 对小鼠模型的急性毒性剂量的 LD50 值为 300 mg/kg (腹腔注射)[1]。
[References]
Chemical & Physical Properties
[ Density]:
1.588 g/cm3
[ Boiling Point ]:
644.9ºC at 760 mmHg
[ Molecular Formula ]:
C20H13N3O6
[ Molecular Weight ]:
391.33400
[ Flash Point ]:
343.8ºC
[ Exact Mass ]:
391.08000
[ PSA ]:
145.78000
[ LogP ]:
3.32450
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DM4675350
- CHEMICAL NAME :
- 4-Benzoxazolecarboxylic acid, 2-(3-hydroxy-2-(((3-hydroxy-2-pyridinyl)carbonyl)amin o)phenyl)-
- CAS REGISTRY NUMBER :
- 80148-45-4
- LAST UPDATED :
- 199209
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C20-H13-N3-O6
- MOLECULAR WEIGHT :
- 391.36
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4293649
Safety Information
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%