gmbs

Names

[ Name ]:
gmbs

[Synonym ]:
1H-Pyrrole-2,5-dione, 1-(4-((2,5-dioxo-1-pyrrolidinyl)oxy)-4-oxobutyl)-
MFCD00036817
(2,5-dioxopyrrolidin-1-yl) 4-(2,5-dioxopyrrol-1-yl)butanoate
1-{4-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-4-oxobutyl}-1H-pyrrole-2,5-dione
1-{4-[(2,5-Dioxopyrrolidin-1-yl)oxy]-4-oxobutyl}-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 1-[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutyl]-

Biological Activity

[Description]:

GMBS is a heterobifunctional cross-linker. GMBS is often used to prepare antibody-enzyme and hapten-carrier protein conjugates.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[References]

[1]. Ding YH, et al. Increasing the Depth of Mass-Spectrometry-Based Structural Analysis of Protein Complexes through the Use of Multiple Cross-Linkers. Anal Chem. 2016 Apr 19;88(8):4461-9.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
461.3±47.0 °C at 760 mmHg

[ Melting Point ]:
123-129ºC

[ Molecular Formula ]:
C₁₂H₁₂N₂O₆

[ Molecular Weight ]:
280.233

[ Flash Point ]:
232.8±29.3 °C

[ Exact Mass ]:
280.069550

[ PSA ]:
101.06000

[ LogP ]:
-1.56

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.595

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
chloroform: 100 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Highly efficient capture and harvest of circulating tumor cells on a microfluidic chip integrated with herringbone and micropost arrays.

Biomed. Microdevices 17(2) , 39, (2015)

Circulating tumor cells (CTCs), which are derived from primary tumor site and transported to distant organs, are considered as the major cause of metastasis. So far, various techniques have been appli...

A chitosan coated monolith for nucleic acid capture in a thermoplastic microfluidic chip.

Biomicrofluidics 8(4) , 044109, (2014)

A technique for microfluidic, pH modulated DNA capture and purification using chitosan functionalized glycidyl methacrylate monoliths is presented. Highly porous polymer monoliths are formed and subse...

Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model.

Oncotarget 5(23) , 12383-97, (2015)

The potential utility of circulating tumor cells (CTCs) to guide clinical care in oncology patients has gained momentum with emerging micro- and nanotechnologies. Establishing the role of CTCs in tumo...