Notoginsenoside R1

Names

[ Name ]:
Notoginsenoside R1

[Synonym ]:
notoginsenoside Rh1
Sanchinoside R1
NOTOGINSENOSIDE
notogisenoside R1
Notoginsenoside R1
(3β,6α,12β)-20-(β-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl-β-D-glucopyranoside
β-D-Glucopyranoside, (3β,6α,12β)-20-(β-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl-
ginsenoside-Rg2
NotoginsenosideR1

Biological Activity

[Description]:

Notoginsenoside R1, the main bioactive component in panaxnotoginseng, is reported to have some neuronal protective, antihypertensive effects. IC50 value:Target:In vitro:In vivo: Notoginsenoside R1 significantly reduce blood pressure in spontaneously hypertensive rats and induce nitric oxide generation through increasing the phosphorylation of iNOS. Notoginsenoside R1 reduces the caudal blood pressure of spontaneously hypertensive rats through induction of iNOS regulated by long non-coding RNA AK094457 [1]. The mice with notoginsenoside R1 treatment showed significant amelioration in the cognitive function and increased choline acetyl transferase expression, as compared to the vehicle treated mice. Notoginsenoside R1 treatment inhibited Aβ accumulation and increased insulin degrading enzyme expression in both APP/PS1 mice and N2a-APP695sw cells [2]. In Notoginsenoside R1 treated rats, expression of TGF-β1and Smad3 at each time point was down-regulated, with statistical significance(P0.05) compared with that in the NDMA group [3].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Amyloid-β

Research Areas >> Others

Natural Products >> Terpenoids and Glycosides

[References]

[1]. Yang Y, et al. Notoginsenoside R1 reduces blood pressure in spontaneously hypertensive rats through a long non-coding RNA AK094457. Int J Clin Exp Pathol. 2015 Mar 1;8(3):2700-9.

[2]. Li Zhi, et al. Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer&aposs Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting Aβ Accumulation. Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzh

[3]. PU Xian-hong, et al. The Effect of Notoginsenoside R1 on TGF-β1/smad3 Signal Pathway in Hepatic Fibrosis Rats. Progress in Modern Biomedicine, 2015-04

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1010.5±65.0 °C at 760 mmHg

[ Melting Point ]:
218 °C

[ Molecular Formula ]:
C₄₇H₈₀O₁₈

[ Molecular Weight ]:
933.127

[ Flash Point ]:
564.9±34.3 °C

[ Exact Mass ]:
932.534485

[ PSA ]:
298.14000

[ LogP ]:
4.42

[ Appearance of Characters ]:
white to off-white

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.614

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: soluble1mg/mL, clear, colorless

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
29389090

Articles

Protective effect of panax notoginseng saponins on acute ethanol-induced liver injury is associated with ameliorating hepatic lipid accumulation and reducing ethanol-mediated oxidative stress.

J. Agric. Food Chem. 63(9) , 2413-22, (2015)

The aim of present study was to evaluate the effects of Panax notoginseng saponins (PNS) against acute ethanol-induced liver injury and further to elucidate its probable mechanisms. Mice were treated ...

A comparative study of using in-line near-infrared spectra, ultraviolet spectra and fused spectra to monitor Panax notoginseng adsorption process.

J. Pharm. Biomed. Anal. 102 , 78-84, (2014)

The step of enriching and purifying saponins by macroporous resin column chromatography is closely related to the safety and efficacy of Panax notoginseng products during their manufacturing processes...

Adulteration and cultivation region identification of American ginseng using HPLC coupled with multivariate analysis.

J. Pharm. Biomed. Anal. 99 , 8-15, (2014)

American ginseng (Panax quinquefolius) is originally grown in North America. Due to price difference and supply shortage, American ginseng recently has been cultivated in northern China. Further, in t...