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Ulinastatin

Names

[ CAS No. ]:
80449-31-6

[ Name ]:
Ulinastatin

[Synonym ]:
3-(2-Furyl)-2,4-dioxaspiro[5.5]undec-8-ene
2,4-Dioxaspiro[5.5]undec-8-ene, 3-(2-furanyl)-
Ulinastatin

Biological Activity

[Description]:

Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease

[References]

[1]. Shangping Fang, et al. Research progress of ulinastatin in the treatment of liver diseases. Int J Clin Exp Pathol. 2020 Nov 1;13(11):2720-2726.  

[2]. Cao C, et al. Ulinastatin Protects Against LPS-Induced Acute Lung Injury By Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators. Shock. 2018 Nov;50(5):595-605.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
331.5±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H16O3

[ Molecular Weight ]:
220.264

[ Flash Point ]:
171.0±16.8 °C

[ Exact Mass ]:
220.109940

[ LogP ]:
2.87

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.549

[ Storage condition ]:
-20℃

Related Compounds