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Indolapril hydrochloride [USAN]

Names

[ CAS No. ]:
80828-32-6

[ Name ]:
Indolapril hydrochloride [USAN]

[Synonym ]:
(2S-(1-(R*(R*)),2α,3aβ,7aβ))-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-1H-indole-2-carboxylic acid hydrochloride
indolapril Hydrochloride
{2S-[1-(R*(R*)),2α,3aβ,7aβ]}-1-(2-{[1-(ethoxycarbonyl)-3-phenylpropyl]amino}-1-oxopropyl)octahydro-1H-indole-2-carboxylic acid hydrochloride
[1-[(2R,3aS,7aS)-2-carboxy-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-1-oxopropan-2-yl]-(1-ethoxy-1-oxo-4-phenylbutan-2-yl)azanium chloride

Biological Activity

[Description]:

Indolapril hydrochloride (CI-907) is an orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor. Indolapril hydrochloride is highly specific in suppressing the contractile or pressor responses to Angiotensin I. Indolapril hydrochloride is a potent antihypertensive agent[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Research Areas >> Metabolic Disease

[References]

[1]. M J Ryan, et al. Antihypertensive effects of CI-907 (indolapril): a novel nonsulfhydryl angiotensin converting enzyme inhibitor. J Pharmacol Exp Ther. 1984 Feb;228(2):312-8.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H35ClN2O5

[ Molecular Weight ]:
466.99800

[ Exact Mass ]:
466.22300

[ PSA ]:
95.94000

[ LogP ]:
3.90410

Related Compounds