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DTSSP Crosslinker

Names

[ CAS No. ]:
81069-02-5

[ Name ]:
DTSSP Crosslinker

[Synonym ]:
N,N'-dioctyl-3,3'-disulfanediyl-bis-propionamide
N,N'-Bis-n-octyl-3,3'-dithiopropionamide
3,3'-disulfanediylbis(N-octylpropanamide)
3,3-dithiobis(sulfosuccinimidyl propionate)
N,N'-di-n-octyl-3,3'-dithiodipropionamide
N,N'-Di-n-octyl-3,3'-dithiodipropionamid
Propanamide,3,3'-dithiobis[N-octyl
(SCH2CH2CONHC8H17)2
3,3'-dithiobis(N-octylpropionamide)

Biological Activity

[Description]:

DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.94

[ Molecular Formula ]:
C14H16N2O14S4

[ Molecular Weight ]:
564.54200

[ Exact Mass ]:
563.94800

[ PSA ]:
303.46000

[ LogP ]:
0.13240

[ Index of Refraction ]:
1.693

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
26-36

Related Compounds