L-Glutamic acid-5-13C

Names

[ Name ]:
L-Glutamic acid-5-13C

[Synonym ]:
I04-8437
[5-13C]glutamic acid
L-Glutamic acid-5-13C
MFCD00144591
(5-13C)-L-Glutamic acid

Biological Activity

[Description]:

L-Glutamic acid-5-13C is the 13C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Signaling Pathways >> Apoptosis >> Apoptosis

Signaling Pathways >> Apoptosis >> Ferroptosis

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Chemical & Physical Properties

[ Melting Point ]:
205ºC (dec.)(lit.)

[ Molecular Formula ]:
C₄₁₃CH₉NO₄

[ Molecular Weight ]:
148.12200

[ Exact Mass ]:
148.05700

[ PSA ]:
100.62000

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3