AH-23848 calcium salt

Names

[ Name ]:
AH-23848 calcium salt

[Synonym ]:
4-Heptenoic acid, 7-[(1R,2R,5S)-5-([1,1'-biphenyl]-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl]-, calcium salt, (4Z)- (2:1)
Calcium bis{(4Z)-7-[(1R,2R,5S)-5-(4-biphenylylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl]-4-heptenoate}

Biological Activity

[Description]:

AH23848 hemicalcium salt is a potent, specific and orally active thromboxane receptor blocker. AH23848 hemicalcium salt inhibits platelet deposition[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[Target]

Thromboxane Receptor[1]

[References]

[1]. Brittain RT, et al. AH23848: a thromboxane receptor-blocking drug that can clarify the pathophysiologic role of thromboxane A2. Circulation. 1985 Dec;72(6):1208-18.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₈H₆₈CaN₂O₁₀

[ Molecular Weight ]:
993.246

[ Exact Mass ]:
992.450012

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Influence of influenza A infection on capsaicin-induced responses in murine airways.

J. Pharmacol. Exp. Ther. 340 , 377-85, (2012)

The principal aim of the study was to determine the influence of influenza A virus infection on capsaicin-induced relaxation responses in mouse isolated tracheal segments and clarify the underlying me...

The prostaglandin E₂ type 4 receptor participates in the response to acute oxidant stress in airway epithelial cells.

J. Pharmacol. Exp. Ther. 341(2) , 552-63, (2012)

Oxidative stress is implicated in the pathogenesis of many inflammatory pulmonary diseases, including cystic fibrosis (CF). Delineating how oxidative stress stimulates CF transmembrane conductance reg...

The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells.

Toxicol. Lett. 198 , 331-41, (2010)

o,p'-Dichlorodiphenyltrichloroethane (o,p'-DDT) is a DDT isomer and xenoestrogen that can induce inflammation and cancer. However, the effect of o,p'-DDT on aromatase is unclear. Thus, we investigated...