dinophysistoxin-1

Names

[ Name ]:
dinophysistoxin-1

[Synonym ]:
9,10-deepithio-9,10-didehydro-35-methyl-acanthifolici
(35R)-9,45-Seco-10-demercapto-9,10-didehydro-35-methylacanthifolicin
DINOPHYSISTOXIN-I
35-methylokadaicacid
DTX1
OKADAIC ACID,35-METHYL
Acanthifolicin,9,10-deepithio-9,10-didehydro-35-methyl
DINOPHYSISTOXIN-1

Biological Activity

[Description]:

Dinophysistoxin 1 (DTX 1, 35-methylokadaic acid) is a causative agent of diarrhetic shellfish poisoning. Dinophysistoxin 1 exerts tumor-promoting activity, serves as a skin irritant as well[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Dinophysistoxin 1 抑制特定的 [3H] 冈田酸与小鼠表皮颗粒部分的结合[1]。

[In Vivo]

Dinophysistoxin 1 (5 μg/mouse; 涂抹在背部; 每周 2 次, 共 30 周) 导致 100 μg 7,12-二甲基苯蒽 (DMBA) 处理组的荷瘤小鼠比例增加[1]。

[References]

[1]. Fujiki H, et al. Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin. Jpn J Cancer Res. 1988 Oct;79(10):1089-93.

Chemical & Physical Properties

[ Density]:
1.27g/cm3

[ Boiling Point ]:
923.3ºC at 760 mmHg

[ Molecular Formula ]:
C₄₅H₇₀O₁₃

[ Molecular Weight ]:
819.02900

[ Flash Point ]:
267.9ºC

[ Exact Mass ]:
818.48200

[ PSA ]:
182.83000

[ LogP ]:
5.45960

[ Index of Refraction ]:
1.581

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AA8227820

CHEMICAL NAME :: Acanthifolicin, 9,10-deepithio-9,10-didehydro-35-methyl-

CAS REGISTRY NUMBER :: 81720-10-7

LAST UPDATED :: 199706

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C45-H70-O13

MOLECULAR WEIGHT :: 819.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 mg/kg/30W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 79,1089,1988