Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide trifluoroacetate salt

Names

[ CAS No. ]:
819048-44-7

[ Name ]:
Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide trifluoroacetate salt

Biological Activity

[Description]:

Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor

[References]

[1]. Doering SR, et al. Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. J Med Chem. 2021 May 13;64(9):5577-5592. doi: 10.1021/acs.jmedchem.0c02041. Epub 2021 Apr 22. Erratum in: J Med Chem. 2023 May 25;66(10):7063-7065.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₁H₇₂N₁₈O₁₁S₂

[ Molecular Weight ]:
1177.36000

[ Exact Mass ]:
1176.51000

[ PSA ]:
559.06000

[ LogP ]:
2.76280