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phenindamine

Names

[ CAS No. ]:
82-88-2

[ Name ]:
phenindamine

[Synonym ]:
Fenindamina
Phenindamine (INN)
Phenindamine [INN:BAN]
Phenindaminum
2-methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine
Nolahist
2-Methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridin
Phenindiamine
Phenindamin
Phenindaminum [INN-Latin]
Fenindamina [INN-Spanish]
Thephorin
Phenindamine

Biological Activity

[Description]:

Phenindamine (Nu 1504) is an antihistamine[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[In Vivo]

Phenindamine (2-10 mg/kg; i.p.; once) shows performance enhancement effect in rats[1]. Animal Model: Adult male Long-Evans strain rats[1] Dosage: 2, 5 and 10 mg/kg Administration: Intraperitoneal injection, once Result: Decreased attention index (AI) and increase the AI variance. Produced a dose-related increase in the performance index (PI).

Chemical & Physical Properties

[ Density]:
1.15g/cm3

[ Boiling Point ]:
416.5ºC at 760 mmHg

[ Melting Point ]:
90-91°

[ Molecular Formula ]:
C19H19N

[ Molecular Weight ]:
261.36100

[ Flash Point ]:
183ºC

[ Exact Mass ]:
261.15200

[ PSA ]:
3.24000

[ LogP ]:
3.85910

[ Index of Refraction ]:
1.652

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NK9460500
CHEMICAL NAME :
1H-Indeno(2,1-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-
CAS REGISTRY NUMBER :
82-88-2
BEILSTEIN REFERENCE NO. :
0221083
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C19-H19-N

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
129 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 124,350,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
265 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 188,271,1970

Synthetic Route

Precursor & DownStream


Related Compounds