10Z-Hymenialdisine
Names
Biological Activity
[Description]:
10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities[1].
[Related Catalog]:
[In Vitro]
10Z-Hymenialdisine displays a moderate effect on (ARK5, VEGFR-2, SAK and PDGFR) protein kinases. 10Z-Hymenialdisine shows a potent inhibition of RAF/MEK-1/MAPK cascade with an IC50 value of 6 nM[1].
[References]
Chemical & Physical Properties
[ Density]:
2.2 g/cm3
[ Melting Point ]:
160-164ºC
[ Molecular Formula ]:
C11H10BrN5O2
[ Molecular Weight ]:
324.13300
[ Exact Mass ]:
323.00200
[ PSA ]:
112.37000
[ LogP ]:
0.85980
[ Index of Refraction ]:
1.911