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Amino-PEG8-amine

Names

[ CAS No. ]:
82209-36-7

[ Name ]:
Amino-PEG8-amine

[Synonym ]:
3,6,9,12,15,18,21,24-Octaoxahexacosane-1,26-diamine
MFCD28122964

Biological Activity

[Description]:

Amino-PEG8-amine is a PEG-based (8 units) PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
493.4±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H40N2O8

[ Molecular Weight ]:
412.519

[ Flash Point ]:
244.7±21.0 °C

[ Exact Mass ]:
412.278473

[ LogP ]:
-3.73

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.467

[ Storage condition ]:
2-8°C

Related Compounds