LP-44

Names

[ Name ]:
LP-44

[Synonym ]:
Psalmotoxin 1
LP44,hydrochloride

Biological Activity

[Description]:

LP44 (hydrochloride) is a selective 5-HT7 agonist with Ki of 0.22 nM. LP44 (hydrochloride) induces hypothermic effect in a dose-dependent manner by intracerebroventricular injection. LP44 (hydrochloride) not causes considerable hypothermic response by intraperitoneal administration[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[In Vivo]

LP44 (hydrochloride) (5.1, 10.3, 20.5, 41.0 nmol; i.c.v.) produces dose-dependent hypothermic effect in CBA mice[1].

[References]

[1]. Naumenko VS,et al. On the role of brain 5-HT7 receptor in the mechanism of hypothermia: comparison with hypothermia mediated via 5-HT1A and 5-HT3 receptor. Neuropharmacology. 2011 Dec;61(8):1360-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₈ClN₃OS

[ Molecular Weight ]:
488.13

[ Exact Mass ]:
487.24200

[ PSA ]:
60.88000

[ LogP ]:
6.48050

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon.

PLoS ONE 6 , e24393, (2011)

Schistosoma infection is thought to lead to down-regulation of the host's immune response. This has been shown for adaptive immune responses, but the effect on innate immunity, that initiates and shap...