6,7-DIHYDROXY-4-(TRIFLUOROMETHYL)COUMARIN

Names

[ Name ]:
6,7-DIHYDROXY-4-(TRIFLUOROMETHYL)COUMARIN

[Synonym ]:
F-methyl-4 dihydroxy-6,7 coumarine
F-methyl-4 esculetine
2H-1-Benzopyran-2-one, 6,7-dihydroxy-4-(trifluoromethyl)-
6,7-Dihydroxy-4-(trifluoromethyl)coumarin
6,7-Dihydroxy-4-(trifluoromethyl)-2H-chromen-2-one

Biological Activity

[Description]:

Antiproliferative agent-35 (Compound 4) inhibits the proliferation of B16 and A549 cells, with IC50s of 13.2 and 9.2 μM resspectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Ping Wang, et al. Design, synthesis and biological evaluation of esculetin derivatives as anti-tumour agents. RSC Advances. Issue 66, 2015

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
380.5±42.0 °C at 760 mmHg

[ Melting Point ]:
214-216ºC(lit.)

[ Molecular Formula ]:
C₁₀H₅F₃O₄

[ Molecular Weight ]:
246.14

[ Flash Point ]:
183.9±27.9 °C

[ Exact Mass ]:
246.013992

[ PSA ]:
70.67000

[ LogP ]:
2.59

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.581

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%