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Atomoxetine

Names

[ CAS No. ]:
83015-26-3

[ Name ]:
Atomoxetine

[Synonym ]:
Hismanal(R)
[3H]-Astemizole
MFCD00865352
benzenepropanamine, N-methyl-g-(2-methylphenoxy)-, (gR)-
Laridal
(3R)-N-Methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine
Histaminos
astemizole
1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazole-2-amine
Paralergin
(gR)-N-Methyl-g-(2-methylphenoxy)benzenepropanamine
tomoxetine [INN_en]
1-(4-fluorophenylmethyl)-N-{1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine
[14C]-Atomoxetine
(R)-N-methyl-3-(2-tolyloxy)-3-(phenyl)propylamine
(-)-Tomoxetine
Tomoxetine [INN]
Retolen
Alermizol
[14C]-Astemizole
(R)-Tomoxetine
(3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine
Atomoxetine
Astemison
Astemizolum
Benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (γR)-
Astemizol
Hismanal

Biological Activity

[Description]:

Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na+ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter

[In Vitro]

Atomoxetine (Tomoxetine) (1-100 µM; 0.5-20 seconds; tsA201 cells) interacts with the human heart muscle sodium channel (hNav1.5) in a state and dose-dependent manner[2].

[In Vivo]

Atomoxetine (Tomoxetine) (0.3-3 mg/kg; i.p.; 0-4 hours; male Sprague-Dawley rats) increases extracellular norepinephrine and dopamine by 3-fold and increases Fos expression in the rat prefrontal cortex[1]. Atomoxetine (Tomoxetine) (0.1-5 mg/kg; i.p. and p.o; for 14 days; spontaneously hypertensive rat) can improve behaviors associated with ADHD in rats[3]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 0.3, 1 and 3 mg/kg Administration: Intraperitoneal injection; for 4 hours Result: Increased the number of cells expressing Fos-like immunoreactivity in PFC 3.7-fold and increased extracellular norepinephrine and dopamine by 3-fold. Animal Model: Spontaneously hypertensive rat (SHR)[3] Dosage: 0.1, 0.3, 1.25 and 5.0 mg/kg Administration: Intraperitoneal injection and oral administration; for 14 days Result: Had non-impact on the measurement of motor activity.

[References]

[1]. Turner M, et, al. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2013 Apr 15;243:28-37.

[2]. Föhr KJ, et, al. Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner. Front Pharmacol. 2021 Feb 25;12:622489.

[3]. Bymaster FP, et, al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
389.0±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H21NO

[ Molecular Weight ]:
255.355

[ Flash Point ]:
164.1±16.0 °C

[ Exact Mass ]:
255.162308

[ PSA ]:
21.26000

[ LogP ]:
3.28

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.552

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ HS Code ]:
2922299090

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%


Related Compounds