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sophoridine

Names

[ CAS No. ]:
83148-91-8

[ Name ]:
sophoridine

[Synonym ]:
matridin-15-one
(2R,3R)-2,3-bis(4-hydroxy-3-methoxybenzyl)-4-butanolide
S-GINSENOSIDE RG3
(2R,3R)-2,3-bis(4-hydroxy-3-methoxybenzyl)butyrolactone
(3R,4R)-rel-Dihydro-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
(E)-3,4-di[(4-hydroxy-3-methoxyphenyl)methyl]dihydro-2(3H)-furanone
SOPHORIDINE (REFERENCE GRADE)
MATRIDIN-15-ONE, (6B,7B,11A)-
rac Matairesinol
(8R,8'R)-(-)-matairesinol
Allomatrine
trans-Dihydro-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone

Biological Activity

[Description]:

d-Sophoridine ((+)-Sophoridine) is the dextro isoform of Sophoridine (HY-N1373), which is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Xu Z, et al. Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells. J Exp Clin Cancer Res. 2017 Sep 11;36(1):124.  

Chemical & Physical Properties

[ Density]:
1.164 g/cm3

[ Boiling Point ]:
396.738ºC at 760 mmHg

[ Molecular Formula ]:
C15H24N2O

[ Molecular Weight ]:
248.36

[ Flash Point ]:
172.748ºC

[ Exact Mass ]:
248.18900

[ PSA ]:
23.55000

[ LogP ]:
1.74750

Related Compounds