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Bonducellin

Names

[ CAS No. ]:
83162-84-9

[ Name ]:
Bonducellin

[Synonym ]:
(E)-7-hydroxy-3-(4'-methoxybenzylidene)chroman-4-one
7-hydroxy-(E)-3-[(4-methoxyphenyl)methylene]chroman-4-one
bonducellin
(E)-7-hydroxy-3-(4-methoxybenzylidene)chroman-4-one
(3E)-2,3-dihydro-7-hydroxy-3-[(4-methoxyphenyl)-methylene]-4H-1-benzopyran-4-one
bonducelline

Biological Activity

[Description]:

Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[References]

[1]. Roy SK, et al. 7-Hydroxy-(E)-3-phenylmethylene-chroman-4-one analogues as efflux pump inhibitors against Mycobacterium smegmatis mc² 155. Eur J Med Chem. 2013 Aug;66:499-507.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H14O4

[ Molecular Weight ]:
282.29

[ Exact Mass ]:
282.08900

[ PSA ]:
55.76000

[ LogP ]:
3.05950

Precursor & DownStream

Precursor

DownStream