FA-Phe-Phe-OH

Names

[ Name ]:
FA-Phe-Phe-OH

[Synonym ]:
N-(3-(2-furyl)acryloyl)phenylalanine
3-(2-FURYL)ACRYLOYL-L-PHENYLALANINE
3-(2-furyl)acryloylglycyl-L-phenylalanine-L-phenylalanine
N-<3-(2-furyl)acryloyl>-Phe-Phe
FA-PHENYLALANINE
Fua-Phe-Phe-OH
N-<3-(2-furyl)acryloyl>-Phe
Fua-Phe-Phe
N-[3-(2-FURYL)ACRYLOYL]-L-PHENYLALANINE
N-<3-<2>Furyl-acryloyl>-L-phenylalanin
FA-Phe-Phe-OH

Biological Activity

[Description]:

FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE). FA-Phe-Phe is also a specific substrate of Cathepsin A[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

[References]

[1]. Mayer M, et al. Mapping the active site of angiotensin-converting enzyme by transferred NOE spectroscopy. J Med Chem. 2000 Jun 1;43(11):2093-9.

[2]. Ostrowska H, et al. Lactacystin, a specific inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin A-like enzyme. Biochem Biophys Res Commun. 1997 May 29;234(3):729-32.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₄N₂O₅

[ Molecular Weight ]:
432.47

[ Exact Mass ]:
432.16900

[ PSA ]:
115.62000

[ LogP ]:
4.51300

[ Storage condition ]:
-20°C

MSDS

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Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Articles

A unique activity assay for carboxypeptidase A in human serum.

Anal. Biochem. 125 , 420, (1982)