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Cetirizine Impurity C

Names

[ CAS No. ]:
83881-59-8

[ Name ]:
Cetirizine Impurity C

[Synonym ]:
2-Chlorocetirizine
Cetirizine 2-Chloro Impurity Dihydrochloride
Acetic acid, 2-[2-[4-[(2-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
UNII-4DG59P89YF
Cetirizine impurity C
UNII:4DG59P89YF
(2-{4-[(2-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)acetic acid

Biological Activity

[Description]:

Cetirizine Impurity C is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Endocrinology
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5.

[2]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
536.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H25ClN2O3

[ Molecular Weight ]:
388.888

[ Flash Point ]:
278.1±28.7 °C

[ Exact Mass ]:
388.155365

[ PSA ]:
53.01000

[ LogP ]:
2.16

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.589

Related Compounds